Donello JE, Loeb JE, Hope TJ . Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. J Virol 1998; 72: 5085–5092.
Hope T . Improving the post-transcriptional aspects of lentiviral vectors. Curr Top Microbiol Immunol 2002; 261: 179–189.
CAS PubMed Google Scholar
Zufferey R, Donello JE, Trono D, Hope TJ . Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 1999; 73: 2886–2892.
Schambach A, Wodrich H, Hildinger M, Bohne J, Krausslich HG, Baum C . Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors. Mol Ther 2000; 2: 435–445.
Popa I, Harris ME, Donello JE, Hope TJ . CRM1-dependent function of a cis-acting RNA export element. Mol Cell Biol 2002; 22: 2057–2067.
f*ckuda M, Asano S, Nakamura T, Adachi M, Yoshida M, Yanagida M et al. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 1997; 390: 308–311.
Fornerod M, Ohno M, Yoshida M, Mattaj IW . CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 1997; 90: 1051–1060.
Bogerd HP, Echarri A, Ross TM, Cullen BR . Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. J Virol 1998; 72: 8627–8635.
Jacobson A, Peltz SW . Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu Rev Biochem 1996; 65: 693–739.
Loeb JE, Cordier WS, Harris ME, Weitzman MD, Hope TJ . Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy. Hum Gene Ther 1999; 10: 2295–2305.
Mastroyiannopoulos NP, Feldman ML, Uney JB, Mahadevan MS, Phylactou LA . Woodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3′ untranslated region transcripts. EMBO Rep 2005; 6: 458–463.
Ramezani A, Hawley TS, Hawley RG . Lentiviral vectors for enhanced gene expression in human hematopoietic cells. Mol Ther 2000; 2: 458–469.
Salmon P, Kindler V, Ducrey O, Chapuis B, Zubler RH, Trono D . High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors. Blood 2000; 96: 3392–3398.
CAS PubMed Google Scholar
Ailles LE, Naldini L . HIV-1-derived lentiviral vectors. Curr Top Microbiol Immunol 2002; 261: 31–52.
CAS PubMed Google Scholar
Kraunus J, Schaumann DH, Meyer J, Modlich U, Fehse B, Brandenburg G et al. Self-inactivating retroviral vectors with improved RNA processing. Gene Therapy 2004; 11: 1568–1578.
Werner M, Kraunus J, Baum C, Brocker T . B-cell-specific transgene expression using a self-inactivating retroviral vector with human CD19 promoter and viral post-transcriptional regulatory element. Gene Therapy 2004; 11: 992–1000.
Bouchard MJ, Schneider RJ . The enigmatic X gene of hepatitis B virus. J Virol 2004; 78: 12725–12734.
Wei Y, Fourel G, Ponzetto A, Silvestro M, Tiollais P, Buendia MA . Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors. J Virol 1992; 66: 5265–5276.
Tang H, Delgermaa L, Huang F, Oishi N, Liu L, He F et al. The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. J Virol 2005; 79: 5548–5556.
Sugata F, Chen HS, Kaneko S, Purcell RH, Miller RH . Analysis of the X gene promoter of woodchuck hepatitis virus. Virology 1994; 205: 314–320.
Flajolet M, Tiollais P, Buendia MA, Fourel G . Woodchuck hepatitis virus enhancer I and enhancer II are both involved in N-myc2 activation in woodchuck liver tumors. J Virol 1998; 72: 6175–6180.
Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F et al. Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol Ther 2005; 12: 763–771.
Kingsman SM, Mitrophanous K, Olsen JC . Potential oncogene activity of the woodchuck hepatitis post-transcriptional regulatory element (WPRE). Gene Therapy 2005; 12: 3–4.
Kondo E, Akatsuka Y, Nawa A, Kuzushima K, Tsujimura K, Tanimoto M et al. Retroviral vector backbone immunogenicity: identification of cytotoxic T-cell epitopes in retroviral vector-packaging sequences. Gene Therapy 2005; 12: 252–258.
Egelhofer M, Brandenburg G, Martinius H, Schult-Dietrich P, Melikyan G, Kunert R et al. Inhibition of human immunodeficiency virus type 1 entry in cells expressing gp41-derived peptides. J Virol 2004; 78: 568–575.
Schambach A, Bohne J, Chandra S, Will E, Margison G, Williams DA, Baum C . Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA-methyltransferase in bone marrow cells. Mol Ther 2005, Oct 10; Epub ahead of print.
Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D et al. A third-generation lentivirus vector with a conditional packaging system. J Virol 1998; 72: 8463–8471.
Baum C, Hegewisch-Becker S, Eckert HG, Stocking C, Ostertag W . Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells. J Virol 1995; 69: 7541–7547.
